Contact: Salimetrics (USA)
Salivary Cortisol
Cortisol (hydrocortisone, Compound F) is the major glucocorticosteroid hormone produced in the adrenal cortex. Cortisol is actively involved in the regulation of calcium absorption, blood pressure maintenance, anti-inflammatory function, gluconeogenesis, gastric acid, pepsin secretion, and immune function. (1,2,3) Cortisol production has a circadian rhythm. (4) Levels peak in the early morning and drop to the […]
Salivary DNA Analysis
Genotyping creates an inter-individual biological profile that enhances the conclusions of observed abnormalities in participant groups. The SalivaLab’s DNA isolation protocol yields high purity, low salt DNA with A260/A280 ratios (indicating protein content) consistently at or above 1.8 and the A260/A230 ratios at or above 1.5. These high quality results with low sample retest rates […]
SARS-CoV-2 (N) IgG Saliva Collection
Print Approved Collection Methods Passive Drool SalivaBio Swabs Special Considerations Consistency in collection methods and sample handling is recommended for optimal results. Production of volumes larger than 1 mL may produce a diluted sample that may necessitate a recollection. Saliva Collection Protocol Before Sample Collection Avoid foods with high sugar or acidity immediately before sample [...]
Salivary SARS-CoV-2 (N) IgG
There is an urgent need to better understand COVID-19 antibody levels and duration of protective immunity for public health considerations. Coronavirus antibody testing in saliva has shown utility as a sensitive and specific serum alternative for large scale immune-surveillance studies (1). Importantly, IgG in saliva is derived from serum, so specificity and reactivity of salivary […]
Salivary IgM
Immunoglobulin M, or IgM, is present in two major forms in the circulation referred to as natural or adaptive (1). Natural IgMs are low affinity pentameric molecules that bind to invading pathogens without requiring prior exposure (2). They act to directly neutralize viruses, activate complement, trigger phagocytosis and drive antibody dependent cell cytotoxicity (3). Adaptive […]
Total IgM Saliva Collection
Print Approved Collection Methods Passive Drool SalivaBio Swabs Special Considerations If collecting with swab devices, it is important to know that concentrations of this analyte may vary depending on the location in the mouth; consistency in swab placement is important. This analyte is sensitive to freeze-thaw degradation. Sample collection, storage, and handling should be carefully [...]
Salivary Interleukin-17A
Human Interleukin-17A (IL-17A), is a disulfide linked glycoprotein that is secreted as a 17.5 kDa homodimer mainly by activated T-helper 17 (Th17) cells (1, 2). IL-17A is an important regulator of inflammation whose signaling induces pro-inflammatory cytokines and chemokines that recruit cells of the innate immune system to sites of infection (2). IL-17A also induces […]
Salivary Interleukin-7
Human Interleukin 7 (IL-7) activity is important for every stage of T cell development and survival of naïve T cells and generation and maintenance of CD4 and CD8 T cell memory. It is also important for the formation of lymphoid structure and defense mechanisms mediated by lymphoid cells. Pathologies associated with IL-7 are those mediated […]
Salivary Interleukin-5
Human Interleukin 5 (IL-5), mainly drives the maturation and maintenance of eosinophils and antibody secreting B cells and is a glycosylated 15.2 kDa disulfide linked homodimer mainly produced by eosiniophils (1) and T helper type 2 (Th2) cells (2). Dysregulation of IL-5 is associated with eosinophilia, atopic dermatitis and pulmonary fibrosis. IL-5 is also expressed […]
Total IgG Saliva Collection
Print Approved Collection Methods Passive Drool SalivaBio Swabs Special Considerations If collecting with swab devices, it is important to know that concentrations of this analyte may vary depending on the location in the mouth; consistency in swab placement is important. This analyte is sensitive to freeze-thaw degradation. Sample collection, storage, and handling should be carefully [...]
Salivary IgG
Immunoglobulin G (IgG) is critical for host immune-defense against infectious pathogens and is the most abundant antibody found in blood. Within the IgG class, there are four subclasses (IgG1, IgG2, IgG3 and IgG4). The term total IgG collectively refers to all IgG subclasses all of which have varying unique reactivities. In most cases an immune […]