Fat Mass and Obesity – FTO

In 2009, two large genome wide association studies about body mass index (BMI) were conducted that further confirmed variants in the FTO gene that are linked to obesity (4, 5). More recently, Claussnitzer et al 2015, showed that the single T-to-C variant in rs1421085 functionally led to a reduction in mitochondrial thermogenesis in adipocyte precursor cells, and an increase in lipid storage, resulting in a direct effect on obesity (6).

Another SNP in the FTO gene, rs1121980, showed a strong association with early onset obesity, and how its effects could be attenuated with physical activity (7, 8). Closer evaluation of the SNPs within the FTO gene can aid researchers in discovering how genetic factors influence an outcome of obesity. For more research and details on MR visit SNPedia here.

When interpreting data from your current study or planning for the future, consider the polymorphisms that influence the regulation of body weight. For a complete list of SNPs available for research, we recommend contacting one of our experts for guidance on the most relevant selections for your research.