(January 28, 2020)

A multi-functional Salivary Total Human IgG ELISA Kit critical to research for sample qualification where oral fluid is used in serological and infectious disease research is now available to investigators. This flexible salivary assay kit provides a much-needed measure of total IgG a means to quantify and index a salivary sample used to characterize an individual’s immune status.

Today, Salimetrics announced an addition to their trusted line of Better Salivary Assay Kits. The new Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ 20+ year commitment to cutting-edge salivary bioscience research. “By measuring total Immunoglobulin G in saliva, researchers can extend the accuracy and ease of use of salivary bioscience into infectious disease research and epidemiological studies,” says Supriya Gaitonde, Ph.D., Salimetrics’ Senior Applications Scientist. “Measuring salivary total IgG is a critical step for sample qualification, used to identify an individual’s immunity to specific disease targets, such as HEV, norovirus, measles, Zika, CMV, EBV, and dengue, among others.” Researchers will also be able to measure total IgG to assure sample integrity when testing for immunoreactivity to any disease specific IgG assay targets to determine an individual’s exposure and immune response to specific immunogens.

“The launch of this Salimetrics Salivary IgG Assay Kit is the product of close interaction with researchers in the public health sector. Working together, the team leveraged Salimetrics’ knowledge in salivary bioscience to create a precise and accurate assay that consistently delivers quality data when testing in the variable matrix that is oral fluid. Now, researchers can have confidence in their salivary immunoreactivity data by assuring adequate levels of total IgG which can be used as inclusion criteria when determining sensitivity and specificity – all leading to better solutions to problems that put populations at risk,” says Steve Granger, Ph.D., Salimetrics’ CSO. “Salivary IgG provides a means that does not depend on a blood draw to qualify a specific population quickly and efficiently in an effort to further identify and control for disease transmission, outbreak, and distribution.”

Immunoglobulin G (IgG) is a key component of the humoral immune system and regulates host immune-defense against pathogenic viruses and microbes. IgG passively diffuses into saliva through the gingival crevicular epithelium, where samples can be conveniently collected. Since IgG in saliva is bioidentical to its serum counterparts, researchers will find it an attractive alternative to blood sampling. Saliva as a non-invasive approach to monitoring immune status has the benefits of increasing participant compliance as well as the speed of sampling anywhere, anytime. “With salivary bioscience, investigators worldwide have gained knowledge through well-designed studies and now may be able to address public health challenges using saliva instead of traditional biological specimens,” says Dr. Gaitonde.

Research has also identified that salivary total IgG is strongly associated with salivary cytokines. A 2020 study, “Salivary total Immunoglobulin G as a surrogate marker of oral immune activity in salivary bioscience research” by Riis, et al., concluded that “Controlling for salivary total IgG may be a feasible, affordable approach to adjusting salivary biomeasure findings for the influence of the oral immune environment when it is not possible or practical to obtain clinical oral health data.” By controlling for populations at high risk of oral inflammation, studies can further improve the validity and reliability of their salivary bioscience data.

The Salimetrics Salivary Total IgG Assay Kit features a dynamic range of 0.3125 – 20 ng/mL, functional sensitivity of 0.94 µg/mL, and average inter and intra-assay coefficients of variation less than 10%. Saliva collection has been validated with SalivaBio’s passive drool protocol and follows the same convenient and reproducible methods that SalivaBio has provided the research community for years.

Salimetrics continues to be a key partner in bringing best-in-class solutions to salivary bioscience research. By using Salimetrics products and services, researchers can find and implement solutions where the full potential of salivary measures have yet to be realized. “With a history of supporting more than 25,000 researchers around the world, these new, high quality assays from Salimetrics will empower a new era in the application of Salivary Bioscience,” says Dr. Granger.

To learn more about the new Salivary Total Human IgG Assay Kit, researchers can visit the Salimetrics Website, or contact researcher support to integrate salivary IgG into their current or future research study.

About Salimetrics:
Salimetrics’ assay kits and CLIA-certified testing services are used to measure salivary analytes related to stress, behavior and development, inflammation, sleep, reproduction, health and immune function. Founded in 1998 by Douglas A. Granger, Ph.D., Salimetrics, LLC support CROs, pharmaceuticals, academic researchers and the immunodiagnostic industry around the world with innovative immunoassay products, non-invasive saliva collection methods, and laboratory testing services.

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