Contact: Salimetrics (USA)
Salivary DNA Analysis
Genotyping creates an inter-individual biological profile that enhances the conclusions of observed abnormalities in participant groups. The SalivaLab’s DNA isolation protocol yields high purity, low salt DNA with A260/A280 ratios (indicating protein content) consistently at or above 1.8 and the A260/A230 ratios at or above 1.5. These high quality results with low sample retest rates […]
Salivary SARS-CoV-2 (IgG) Antibody Panel
The SARS-CoV-2 IgG Antibody Assay, 3-Plex (S-Protein, N-Protein, & RBD) is a serological assay that recognizes antibodies to SARS-CoV-2 Nucleocapsid, Spike 1 and Spike 1 Receptor Binding Domain (RBD) in the same saliva (or serum) sample. Coronavirus antibody testing in saliva has shown utility as a sensitive and specific serum alternative for large scale immune-surveillance […]
Salivary SARS-CoV-2 (N) IgG
There is an urgent need to better understand COVID-19 antibody levels and duration of protective immunity for public health considerations. Coronavirus antibody testing in saliva has shown utility as a sensitive and specific serum alternative for large scale immune-surveillance studies (1). Importantly, IgG in saliva is derived from serum, so specificity and reactivity of salivary […]
Salivary Interleukin-17A
Human Interleukin-17A (IL-17A), is a disulfide linked glycoprotein that is secreted as a 17.5 kDa homodimer mainly by activated T-helper 17 (Th17) cells (1, 2). IL-17A is an important regulator of inflammation whose signaling induces pro-inflammatory cytokines and chemokines that recruit cells of the innate immune system to sites of infection (2). IL-17A also induces […]
Salivary Interleukin-7
Human Interleukin 7 (IL-7) activity is important for every stage of T cell development and survival of naïve T cells and generation and maintenance of CD4 and CD8 T cell memory. It is also important for the formation of lymphoid structure and defense mechanisms mediated by lymphoid cells. Pathologies associated with IL-7 are those mediated […]
Salivary Interleukin-5
Human Interleukin 5 (IL-5), mainly drives the maturation and maintenance of eosinophils and antibody secreting B cells and is a glycosylated 15.2 kDa disulfide linked homodimer mainly produced by eosiniophils (1) and T helper type 2 (Th2) cells (2). Dysregulation of IL-5 is associated with eosinophilia, atopic dermatitis and pulmonary fibrosis. IL-5 is also expressed […]
Salivary Interleukin-13
Human interleukin-13 (IL-13) is secreted by a variety of immune cells as a 15.8 kDa, glycosylated monomeric cytokine involved in a number of biological processes. It stimulates B-cell proliferation, macrophage activation, immunoglobulin production, protein secretion, and phosphorylation of Stat6 protein. IL-13 is a central regulator of IgE synthesis, mucus hypersecretion and a mediator of allergic […]
Salivary Interleukin-12p70
Human interleukin-12p70 (IL-12p70) activates T cells and natural killer cells that stimulate the production of IFN-γ. It is involved in a number of disorders including periodontitis (1) and chronic toxoplasmosis (2) among others. IL-12p70 is a disulfide-linked heterodimer consisting of IL-12a (p35 subunit) and IL-12b (p40 subunit), mainly produced by macrophages and T lymphocytes and […]
Salivary Interleukin-10
Human interleukin-10 (IL-10). IL-10 is mainly produced by monocytes and some lymphocytes as a 20.5 kDa, glycosylated homodimeric protein. It is an anti-inflammatory cytokine that inhibits the synthesis of numerous cytokines (including IFN-γ, IL-2, IL-3, TNF-α, TNF-β, and GM-CSF) that suppress Th1 proinflammatory responses involved in promoting phagocytosis. Secretion is at very low levels in […]
Salivary Interleukin-2
IL-2 Human interleukin-2 (IL-2) has several roles in the immune system, immune tolerance and immunity against pathogens, primarily by its direct effects on T lymphocytes. In general, depending on the context, IL-2 can function to initiate or dampen immune responses. IL-2 promotes the differentiation of immature T lymphocytes into regulatory T cells, which help protect […]
Salivary Interferon Gamma
*Available as part of the Salimetrics Cytokine Panel – Not available as an individual test* Human interferon gamma (IFN-γ, IFN-gamma) is mainly produced by lymphocytes as a glycosylated 19.3 kilo Dalton (kDa) cytokine that exists as a non-covalently linked homodimer. In general, IFN-gamma is a central regulator of innate and adaptive immune responses mounted against […]
Salivary Transferrin
In the bloodstream the majority of steroid hormones are bound either to non-specific proteins such as albumin or to specific proteins such as corticosteroid binding globulin (CBG) or sex hormone binding globulin (SHBG). These protein molecules are generally too large to diffuse from the blood stream into the saliva glands. Consequently, only the 1-15% of […]
Salivary Testosterone
Testosterone is an anabolic steroid hormone synthesized from androstenedione in the Leydig cells of the testes of males and, in smaller quantities, in the ovaries of females. (1) Small amounts are also secreted by the adrenal glands in both sexes. In both men and women a large portion of total testosterone production occurs in peripheral tissues by conversion of circulating DHEA-S, DHEA, and androstenedione. […]
Salivary SIgA
Secretory Immunoglobulin A (SIgA) is a subclass of Immunoglobulin A (IgA), an antibody that plays a critical role in mucosal immunity. SIgA is the main immunoglobulin found in mucous secretions from tear glands, salivary glands, mammary glands, the respiratory system, the genito-urinary tract, and the gastrointestinal tract. (1) SIgA is not synthesized by mucosal epithelial cells in […]