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Salivary Interleukin-6 as a potential non-invasive biomarker for Huntington’s Disease progression
Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects. Corey-Bloom et al. (2020) International Journal of Molecular Sciences ABSTRACT:Growing evidence suggests that inflammatory responses, in both the brain and peripheral tissues, contribute to disease pathology in Huntington’s disease (HD), an inherited, progressive neurodegenerative disorder […]
Increases in adolescent’s salivary cortisol levels may show adolescent-driven stress transmission in families
Daily parent-adolescent cortisol associations: Unpacking the direction of effects. Lippold MA, et al., (2020) Psychoneuroendocrinology ABSTRACT:Prior studies suggest bidirectional relationships between parent and adolescent behavior. This study examined how parents and their adolescent child’s cortisol patterns are associated across days and if there are bidirectional associations between parent and child cortisol. Participants included two samples […]
Improved salivary HCMV IgG antibody assays may be a viable option for serum testing
Correspondence between Cytomegalovirus IgG Levels Measured in Saliva and Serum Riis, JL. Et al. (2020) Journal of Clinical Medicine. ABSTRACT:Cytomegalovirus (HCMV) infects more than 80% of the global population. While mostly asymptomatic, HCMV infection can be serious among the immunocompromised, and it is implicated in chronic disease pathology in adulthood. Large-scale minimally-invasive HCMV screening could […]
Methods for highly sensitive measurement of SARS-CoV-2 viral RNA and antibodies from a single saliva sample
Ultrasensitive measurement of both SARS-CoV2 RNA and serology from saliva D Ter-Ovanesyan et al., (2021) medRxiv ABSTRACT: Tests for COVID-19 generally measure SARS-CoV2 viral RNA from nasal swabs or antibodies against the virus from blood. It has been shown, however, that both viral particles and antibodies against those particles are present in saliva, which is […]
Behavior problems in youth may show a higher salivary cortisol – alpha-amylase coordination
The within-person coordination of HPA and ANS activity in stress response: Relation with behavior problems FR Chen et al., (2020) Psychoneuroendocrinology ABSTRACT: This study tests the within-person coordination of HPA and ANS activity in response to stress and examines for the first time the association between such coordination and behavior problems in minority urban children. […]
In Memoriam: Dr. Mark Laudenslager
It is with a heavy heart that we learn of the loss of a great achiever in the field of Behavioral Immunology & Endocrinology. Dr. Mark Laudenslager from the University of Colorado Anschutz Medical Campus passed on Friday, December 4th, 2020 due to medical complications from an ongoing condition. This week we mourn the loss […]
Utility of routine salivary COVID-19 testing to prevent outbreaks in frontline healthcare workers
Routine saliva testing for the identification of silent COVID-19 infections in healthcare workers Zhang, K et al., (2020) MedRxiv ABSTRACT: Objective: Current COVID-19 guidelines recommend symptom-based screening and regular nasopharyngeal (NP) testing for healthcare personnel in high-risk settings. We sought to estimate case detection percentages with various routine NP and saliva testing frequencies. Design: Simulation […]
Another Salivary Bioscience Breakthrough: Research Study Obtains 100% Sensitivity and Specificity for COVID-19 Serology with Support from Salimetrics
(November 24, 2020) Recently, infectious disease experts at Johns Hopkins and Emory University, in collaboration with Salivary Bioscience experts from Salimetrics and the University of California, Irvine, published a preliminary report in the Journal of Clinical Microbiology for a saliva/oral fluid-based study related to COVID-19 immunology. At a critical juncture during the era of COVID-19, [...]
Behavior problems in youth may show a higher salivary cortisol – alpha amylase coordination
The within-person coordination of HPA and ANS activity in stress response:Relation with behavior problems FR Chen et al., (2020) Psychoneuroendocrinology ABSTRACT: This study tests the within-person coordination of HPA and ANS activity in response to stress and examines for the first time the association between such coordination and behavior problems in minority urban children. Participants, […]
Salivary Inflammatory Cytokines rise during the acute stress response
The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis Szabo Y Z, et al. ( 2020) Brain, Behavior, and Immunity ABSTRACT: Background: Salivary biomarkers of inflammation are increasingly used in stress research. This systematic review and meta-analysis provides a quantitative summary of changes in salivary inflammatory markers in response […]
SARS-CoV-2 Saliva-Based Antibody Testing as a Non-Invasive and Scalable Alternative to Blood-Based Antibody Testing
COVID-19 Serology at population scale: SARS-CoV-2-specific antibody responses in saliva Pisanic et al., (2020) J Clin Microbiol. ABSTRACT: SARS-CoV-2 is the cause of an ongoing pandemic that has infected over 36 million and killed over 1 million people. Informed implementation of government public health policies depends on accurate data on SARS-CoV-2 immunity at population scale. […]
Salimetrics Supports COVID-19 Research Efforts with Saliva-Based SARS-CoV-2 Antibody Assay for Surveillance
(October 13, 2020) A sensitive, precise, rapidly scalable, COVID-19 (SARS-CoV-2, N) Salivary IgG ELISA Kit from Salimetrics is now available for pre-order in an effort to support serological surveillance research. This oral fluid antibody assay utilizes easy-to-collect, non-invasive saliva samples to identify prior COVID-19 exposure, enabling seroprevalence research studies to occur at a population-based level. [...]
Accurate Covid-19 Serological Surveillance Using Easy-to-Collect Saliva Samples
(September 28, 2020) Salimetrics, the leaders in Salivary Bioscience, announce the launch of their high sensitivity, salivary SARS-CoV-2 IgG assay for serological surveillance. A new serological assay is poised to enhance COVID-19 surveillance efforts with a simple, easy-to-collect saliva sample. “Today, Salimetrics is pleased to announce that after rigorous evaluation and validation, the Salimetrics SalivaLab [...]
High Levels of Salivary Testosterone May Play a Role In Negative Paternal Parenting
Testosterone Associations with Parents’ Child Abuse Risk and At-Risk Parenting: A Multimethod Longitudinal Examination Rodriguez CM, et al. (2020) Child Maltreatment ABSTRACT: The current investigation considered salivary testosterone as a potential biomarker of physical child abuse risk. Parents enrolled in a prospective, longitudinal, multimethod study beginning prenatally provided saliva when their toddlers were 18 months […]
Zoo Exhibits may have a significant positive impact on stress reduction
Changes in human health parameters associated with an immersive exhibit experience at a zoological institution Coolman AA, et al. (2020) PloS one. ABSTRACT: Zoological institutions often use immersive, naturalistic exhibits to create an inclusive atmosphere that is inviting for visitors while providing for the welfare of animals in their collections. In this study, we investigated […]